EC Number   |
Cofactor |
Reference |
|---|
    1.2.1.105 | more |
the complex contains 12.1 mol FAD per mol of enzyme complex |
349019 |
| 1.2.1.105 | NAD+ |
- |
654557, 654854, 655234, 656174, 656265, 656580, 656591, 687856, 699659, 700476, 700812, 758747 |
| 1.2.1.105 | thiamine diphosphate |
- |
349038, 349042, 656265, 656591, 676088, 685238, 689950, 700476, 700812, 740884, 758747 |
| 1.2.1.105 | thiamine diphosphate |
2-oxoglotarate dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is dependent on thiamine diphosphate. Thiamine diphosphate attacks the alpha-carbon of 2-oxoglutarate and decarboxylates the substrate. The thiamine diphosphate reaction adduct then reductively acylates the lipoyl moiety of EC 2.3.1.61 |
349038 |
| 1.2.1.105 | thiamine diphosphate |
2-oxoglutarate dehydrogenase complex contains thiamine diphosphate |
349026 |
| 1.2.1.105 | thiamine diphosphate |
activates the 2-oxoglutarate dehydrogenase complex activity, involved in conformational changes |
656580 |
| 1.2.1.105 | thiamine diphosphate |
covalently bound to the enzyme |
348910 |
| 1.2.1.105 | thiamine diphosphate |
formation of a precatalytic complex SE between the substrate and the 2-oxoglutarate dehydrogenase component before the catalytic complex ES, in which the substrate is added to the thiamin diphosphate cofactor |
349044 |
| 1.2.1.105 | thiamine diphosphate |
Km: 0.3 mM |
349015 |
| 1.2.1.105 | thiamine diphosphate |
required , 2-oxoglutarate dehydrogenase complex |
349003, 349015, 349018, 349024, 349032 |
