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Literature summary for 1.2.1.105 extracted from

  • Yeaman, S.J.
    The mammalian 2-oxoacid dehydrogenases: a complex family (1986), Trends Biochem. Sci., 11, 293-296.
No PubMed abstract available
Search for more literature for 1.2.1.105

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Sus scrofa 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutarate + lipoamide Sus scrofa enzyme of the TCA cycle S-succinyldihydrolipoamide + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) Sus scrofa
a
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Sus scrofa
a

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + lipoamide
-
 Sus scrofa S-succinyldihydrolipoamide + CO2
-
 ?
2-oxoglutarate + lipoamide enzyme of the TCA cycle Sus scrofa S-succinyldihydrolipoamide + CO2
-
 ?

Subunits

Subunits Comment Organism
More structure of the 2-oxoglutarate dehydrogenase complex: E1 (EC 1.2.4.2): 12 subunits per complex (each with 113000 Da), E2 (EC 2.3.1.61): 24 subunits per complex (each with 48000 Da), E3 (EC 1.8.1.4): 12 subunits per complex (each with 55000 Da) Sus scrofa

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate covalently bound to the enzyme Sus scrofa