General Stability | Organism |
---|---|
2-oxoglutarate stabilizes against dilution | Aspergillus niger |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cis-aconitate | 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
K+ | 50 mM, 56% inhibition, 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
Na+ | 50 mM, 48% inhibition, 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
NADH | 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
NH4+ | 50 mM, 70% inhibition, 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
oxalacetate | 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
succinate | 2-oxoglutarate dehydrogenase complex | Aspergillus niger |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
2-oxoglutarate | - |
Aspergillus niger |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus niger | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Aspergillus niger |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | highest activity found in rapidly growing mycelium, glucose-NH4+ or glucose-peptone medium | Aspergillus niger | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + lipoamide | - |
Aspergillus niger | S-succinyldihydrolipoamide + CO2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
2-oxoglutarate dehydrogenase complex | Aspergillus niger |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 8.5 | pH 7.0: about 70% of maximal activity, pH 8.5: about 70% of maximal activity, 2-oxoglutarate dehydrogenase complex | Aspergillus niger |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | required , 2-oxoglutarate dehydrogenase complex | Aspergillus niger | |
thiamine diphosphate | Km: 0.3 mM | Aspergillus niger |