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Literature summary for 1.2.1.105 extracted from

  • Meixner-Monori, B.; Kubicek, C.P.; Habison, A.; Kubicek-Pranz, E.M.; Roehr, M.
    Presence and regulation of the alpha-ketoglutarate dehydrogenase multienzyme complex in the filamentous fungus Aspergillus niger (1985), J. Bacteriol., 161, 265-271.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
2-oxoglutarate stabilizes against dilution Aspergillus niger

Inhibitors

Inhibitors Comment Organism Structure
cis-aconitate 2-oxoglutarate dehydrogenase complex Aspergillus niger
K+ 50 mM, 56% inhibition, 2-oxoglutarate dehydrogenase complex Aspergillus niger
Na+ 50 mM, 48% inhibition, 2-oxoglutarate dehydrogenase complex Aspergillus niger
NADH 2-oxoglutarate dehydrogenase complex Aspergillus niger
NH4+ 50 mM, 70% inhibition, 2-oxoglutarate dehydrogenase complex Aspergillus niger
oxalacetate 2-oxoglutarate dehydrogenase complex Aspergillus niger
succinate 2-oxoglutarate dehydrogenase complex Aspergillus niger

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
2-oxoglutarate
-
Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Aspergillus niger

Source Tissue

Source Tissue Comment Organism Textmining
mycelium highest activity found in rapidly growing mycelium, glucose-NH4+ or glucose-peptone medium Aspergillus niger
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + lipoamide
-
Aspergillus niger S-succinyldihydrolipoamide + CO2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
2-oxoglutarate dehydrogenase complex Aspergillus niger

pH Range

pH Minimum pH Maximum Comment Organism
7 8.5 pH 7.0: about 70% of maximal activity, pH 8.5: about 70% of maximal activity, 2-oxoglutarate dehydrogenase complex Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate required , 2-oxoglutarate dehydrogenase complex Aspergillus niger
thiamine diphosphate Km: 0.3 mM Aspergillus niger