EC Number   |
General Information |
Reference |
|---|
   3.4.22.61 | physiological function |
activation of caspase 8 is involved in Fas-induced apoptosis in neonatal astrocytes |
710108 |
| 3.4.22.61 | metabolism |
activation of caspase 8 is upstream of caspase 3 activation |
717470 |
| 3.4.22.61 | more |
active caspase-8 colocalizes with internalized TNF-R1 receptosomes |
717539 |
| 3.4.22.61 | physiological function |
apoptosis is mediated with caspase-8 activation |
710618 |
| 3.4.22.61 | physiological function |
caspase 8 can initiate apoptosis in response to cell surface receptor activation, but it is also required for embryonic development and immune cell proliferation, defined by suppression of receptor-interacting protein kinase 3, a kinase that triggers an alternative form of cell death called programmed necrosis. The extrinsic apoptosis, is mediated by a group of receptors of the tumour necrosis factor, TNF, superfamily called the death receptors. Caspase 8 is further implicated in cell motility, metastasis, and suppression of inflammation. The non-apoptotic roles of FADD and caspase 8 are involved the suppression of RIPK3-dependent programmed necrosis, the caspase 8FLIP heterodimer is implicated in carrying out the suppression of RIPK3 signalling. Mechanism of caspase 8 activation, detailed overview |
718154 |
| 3.4.22.61 | physiological function |
caspase 8 inhibits programmed necrosis by processing CYLD. Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis. CYLD is cleaved by caspase 8 to promote survival |
718144 |
| 3.4.22.61 | physiological function |
caspase 8 inhibits programmed necrosis by processing CYLD. Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis. CYLD is cleaved by caspase 8 to promote survival. TNF-treated caspase-8-sufficient Jurkat T cells dying by apoptosis but remain unchanged in the caspase-8-deficient cells dying by necrosis |
718144 |
| 3.4.22.61 | physiological function |
caspase 8 is a key molecule of apoptosis in hepatocellular carcinoma. Methylation of caspase 8 and positive expression of its gene product is significantly correlated with high apoptotic indices |
710203 |
| 3.4.22.61 | physiological function |
caspase 8 is an initiator caspase for caspase 3 during H2O2-induced apoptosis |
717470 |
| 3.4.22.61 | physiological function |
caspase 8 is involved in apoptosis, trophoblast differentiation process, regulation of inflammatory processes, lymphocyte proliferation, cell migration, and cell differentiation with or without enucleation |
710260 |
