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Literature summary for 3.4.22.61 extracted from

  • Barca, O.; Carneiro, C.; Costoya, J.A.; Senaris, R.M.; Arce, V.M.
    Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8 (2010), Neurosci. Lett., 479, 206-210.
    View publication on PubMed
Search for more literature for 3.4.22.61

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-IETD-fluoromethylketone
-
 Rattus norvegicus
carboxyfluorescein-LETD-fluoromethylketone
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
fetus
-
 Rattus norvegicus
-
primary cell
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
caspase 8
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus caspase 8 mRNA is undetectable in neonatal astrocytes down
Rattus norvegicus treatment of neonatal astrocytes with the demethylating agent 5-aza-dC leads to an increase in caspase 8mRNA levels in originally caspase 8-negative neonatal astrocytes up

General Information

General Information Comment Organism
malfunction silencing of caspase 8 gene is a key factor controlling the outcome of neonatal astrocytes upon Fas engagement, restoration of caspase 8 expression triggers apoptotic cell death in primary neonatal astrocytes Rattus norvegicus
physiological function activation of caspase 8 is involved in Fas-induced apoptosis in neonatal astrocytes Rattus norvegicus