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Literature summary for 3.4.22.61 extracted from

  • Wu, Y.; Wang, D.; Wang, X.; Wang, Y.; Ren, F.; Chang, D.; Chang, Z.; Jia, B.
    Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells (2011), Cell. Physiol. Biochem., 27, 539-546.
    View publication on PubMed
Search for more literature for 3.4.22.61

Inhibitors

Inhibitors Comment Organism Structure
additional information both the caspase 3 and 9 inhibitors Z-DEVD-fluoromethylketone and Z-LEHD-fluoromethylketone fail to inhibit the activation of caspase 8 Homo sapiens
Z-IETD-fluoromethylketone a strong caspase-8 specific inhibitor, moderate inhibitory role of Z-IETD-fluoromethylketone on the H2O2-induced cell number decrease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Homo sapiens caspase-3 is activated through caspase-8 during H2O2-induced apoptosis in HeLa cells caspase-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-IETD-4-trifluoromethylcoumarin 7-amide + H2O
-
 Homo sapiens N-acetyl-IETD + 7-amino-4-trifluoromethylcoumarin
-
 ?
pro-caspase-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?
pro-caspase-3 + H2O caspase-3 is activated through caspase-8 during H2O2-induced apoptosis in HeLa cells Homo sapiens caspase-3 + ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 8
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism activation of caspase 8 is upstream of caspase 3 activation Homo sapiens
physiological function caspase 8 is an initiator caspase for caspase 3 during H2O2-induced apoptosis Homo sapiens