EC Number   |
General Information |
Reference  |
|---|
   2.4.2.12 | physiological function |
cardiac-specific overexpression of Nampt in transgenic mice increases NAD+ content in the heart, prevents downregulation of Nampt, and reduces the size of myocardial infarction and apoptosis in response to prolonged ischemia and ischemia/reperfusion. Upregulation of Nampt significantly increases NAD+ and ATP concentrations, whereas downregulation of Nampt significantly decreases them. Expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2-positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux |
703243 |
| 2.4.2.12 | malfunction |
implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis |
722560 |
| 2.4.2.12 | physiological function |
growth factor, cytokine and nicotinamide phosphoribosyltransferase |
722560 |
| 2.4.2.12 | physiological function |
required for de novo lipogenesis in tumor cells |
723576 |
| 2.4.2.12 | physiological function |
the enzyme is involved in cancer |
735872 |
| 2.4.2.12 | physiological function |
nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy |
736003 |
| 2.4.2.12 | physiological function |
the enzyme is essential for early embryonic development |
736091 |
| 2.4.2.12 | malfunction |
enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp |
736227 |
| 2.4.2.12 | physiological function |
enzyme activity is essential for survival of resting lymphocytes |
736227 |
| 2.4.2.12 | malfunction |
enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition |
736436 |
