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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12physiological function cardiac-specific overexpression of Nampt in transgenic mice increases NAD+ content in the heart, prevents downregulation of Nampt, and reduces the size of myocardial infarction and apoptosis in response to prolonged ischemia and ischemia/reperfusion. Upregulation of Nampt significantly increases NAD+ and ATP concentrations, whereas downregulation of Nampt significantly decreases them. Expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2-positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux 703243
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12metabolism enhanced enzyme expression increases cellular NAD+ concentration no more than 2fold 760043
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12physiological function enzyme activity is essential for survival of resting lymphocytes 736227
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12malfunction enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp 736227
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12malfunction enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition 736436
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12physiological function enzyme overexpression serves to reduce degrees of tumor necrosis factor-alpha-induced endothelial cell apoptosis 758625
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12physiological function enzyme upregulation in human pulmonary artery endothelial cells is associated with pulmonary arterial hypertension progression and pulmonary vascular remodeling 760186
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12metabolism enzyme-mediated NAD biosynthesis may modify cocaine behavioral effects through sirtuin 1. The enzyme regulates cocaine reward through the NAD/sirtuin 1 pathway 759157
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12physiological function growth factor, cytokine and nicotinamide phosphoribosyltransferase 722560
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.12malfunction homozygous enzyme knockout results in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24% body weight loss 759022
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