EC Number   |
General Information |
Reference |
|---|
   2.1.1.321 | drug target |
overexpressed PRMT7 in clear cell renal cell carcinoma (ccRCC) cells acts as an oncogene to promote the growth of renal cell carcinoma through regulating the beta-catenin/C-MYC axis, thereby providing new strategies and targets for the treatment of ccRCC patients |
756929 |
| 2.1.1.321 | malfunction |
defects in muscle stem cells (satellite cells) and immune cells are found in mouse Prmt7 homozygous knockout |
755900 |
| 2.1.1.321 | malfunction |
defects in muscle stem cells (satellite cells) and immune cells are found in mouse Prmt7 homozygous knockouts |
755900 |
| 2.1.1.321 | malfunction |
humans lacking PRMT7 are characterized by significant intellectual developmental delays, hypotonia, and facial dysmorphisms |
755900 |
| 2.1.1.321 | malfunction |
humans lacking PRMT7 are characterized by significant intellectual developmental delays, hypotonia, and facial dysmorphisms. The overexpression of the PRMT7 gene is correlated with cancer metastasis in humans |
755900 |
| 2.1.1.321 | malfunction |
knockdown of medaka prmt7 does not reduce the total number of primordial germ cells (PGCs) in vivo but significantly affects PGCs distribution during embryonic development |
757338 |
| 2.1.1.321 | malfunction |
PRMT7-deficient mouse embryonic fibroblasts (MEFs) exhibit a premature cellular senescence with accompanied increase in the cell cycle inhibitors p16 and p21. PRMT7 depletion results in reduced Shh signaling activity in MEFs |
756384 |
| 2.1.1.321 | malfunction |
stress granule formation, in the face of eIF2alpha-dependent cellular stresses, is significantly diminished in PRMT7-knockdown |
757636 |
| 2.1.1.321 | metabolism |
overexpression of the PRMT7 gene is correlated with cancer metastasis in humans |
755900 |
| 2.1.1.321 | physiological function |
arginine methylation is an important posttranslational modification and catalyzed by a family of protein arginine methyltransferases. PRMT7 plays important roles in multiple biological processes in mammals. PRMT7 may be involved in germ cell development in Oryzias latipes |
757338 |
