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Literature summary for 2.1.1.321 extracted from

  • Liu, F.; Wan, L.; Zou, H.; Pan, Z.; Zhou, W.; Lu, X.
    PRMT7 promotes the growth of renal cell carcinoma through modulating the beta-catenin/C-MYC axis (2020), Int. J. Biochem. Cell Biol., 120, 105686 .
    View publication on PubMed
Search for more literature for 2.1.1.321

Inhibitors

Inhibitors Comment Organism Structure
adenosine dialdehyde blocks the action of PRMT7 in ccRCC cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [beta-catenin]-L-arginine Homo sapiens the enzyme (PRMT7) upregulates the expression of C-MYC via methylating beta-catenin and inhibiting the ubiquitin-mediated degradation of beta-catenin S-adenosyl-L-homocysteine + [beta-catenin]-Nomega-methyl-L-arginine
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVM4
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-

Source Tissue

Source Tissue Comment Organism Textmining
renal cell carcinoma cell overexpression in renal cell carcinoma Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [beta-catenin]-L-arginine
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 Homo sapiens S-adenosyl-L-homocysteine + [beta-catenin]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [beta-catenin]-L-arginine the enzyme (PRMT7) upregulates the expression of C-MYC via methylating beta-catenin and inhibiting the ubiquitin-mediated degradation of beta-catenin Homo sapiens S-adenosyl-L-homocysteine + [beta-catenin]-Nomega-methyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT7
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 Homo sapiens

General Information

General Information Comment Organism
drug target overexpressed PRMT7 in clear cell renal cell carcinoma (ccRCC) cells acts as an oncogene to promote the growth of renal cell carcinoma through regulating the beta-catenin/C-MYC axis, thereby providing new strategies and targets for the treatment of ccRCC patients Homo sapiens
physiological function the enzyme (PRMT7) regulates the expression of C-MYC, which plays an important role in promoting ccRCC cell proliferation, and it accelerates the tumor development of RCC in a C-MYC-dependent manner. It upregulates the expression of C-MYC via methylating beta-catenin and inhibiting the ubiquitin-mediated degradation of beta-catenin Homo sapiens