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Literature summary for 2.1.1.321 extracted from

  • Jain, K.; Clarke, S.G.
    PRMT7 as a unique member of the protein arginine methyltransferase family A review (2019), Arch. Biochem. Biophys., 665, 36-45 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.321

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Caenorhabditis elegans
-
 Trypanosoma brucei brucei

Inhibitors

Inhibitors Comment Organism Structure
NaCl sodium chloride strongly inhibits the activity of the human enzyme. Half maximal activity is seen at about 25 mM with a peptide substrate based on histone H2B and about 200 mM for the GST-GAR protein substrate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm entirely localized to the cytoplasmic fraction in mouse embryo fibroblasts Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [histone H4R17]-L-arginine Homo sapiens crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3 S-adenosyl-L-homocysteine + [histone H4R17]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R17]-L-arginine Mus musculus crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3 S-adenosyl-L-homocysteine + [histone H4R17]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R3]-L-arginine Homo sapiens
-
 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R3]-L-arginine Mus musculus
-
 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega-dimethyl-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q9XW42
-
-
Homo sapiens Q9NVM4
-
-
Mus musculus Q922X9
-
-
Trypanosoma brucei brucei Q582G4
-
-
Trypanosoma brucei brucei 927 Q582G4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
-
HEK-293T cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [protein]-L-arginine the enzyme has a strong preference for RXR motifs surrounded by basic amino acids Homo sapiens 2 S-adenosyl-L-homocysteine + [protein]-Nomega-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [protein]-L-arginine the enzyme has a strong preference for RXR motifs surrounded by basic amino acids Mus musculus 2 S-adenosyl-L-homocysteine + [protein]-Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R17]-L-arginine crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3 Homo sapiens S-adenosyl-L-homocysteine + [histone H4R17]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R17]-L-arginine crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3 Mus musculus S-adenosyl-L-homocysteine + [histone H4R17]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R3]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [histone H4R3]-Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4R3]-L-arginine
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H4R3]-Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [protein]-L-arginine substrate preference for arginine residues in R-X-R motifs with additional flanking basic amino acid residues Homo sapiens S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [protein]-L-arginine substrate preference for arginine residues in R-X-R motifs with additional flanking basic amino acid residues Mus musculus S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT7
-
 Homo sapiens
PRMT7
-
 Mus musculus
PRMT7
-
 Caenorhabditis elegans
PRMT7
-
 Trypanosoma brucei brucei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
10 25
-
 Homo sapiens
10 25
-
 Mus musculus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
10 37 the enzyme is most active from 10°C to 25°C with less than 10% of the optimal activity at 37°C in vitro Homo sapiens
10 37 the enzyme is most active from 10°C to 25°C with less than 10% of the optimal activity at 37°C in vitro Mus musculus

General Information

General Information Comment Organism
malfunction defects in muscle stem cells (satellite cells) and immune cells are found in mouse Prmt7 homozygous knockout Mus musculus
malfunction defects in muscle stem cells (satellite cells) and immune cells are found in mouse Prmt7 homozygous knockouts Mus musculus
malfunction humans lacking PRMT7 are characterized by significant intellectual developmental delays, hypotonia, and facial dysmorphisms Homo sapiens
malfunction humans lacking PRMT7 are characterized by significant intellectual developmental delays, hypotonia, and facial dysmorphisms. The overexpression of the PRMT7 gene is correlated with cancer metastasis in humans Homo sapiens
metabolism overexpression of the PRMT7 gene is correlated with cancer metastasis in humans Homo sapiens
physiological function in human cell lines PRMT7 expression and subsequent methylation of histone H4R3 leads to repression of DNA damage repair genes such as APEX2, POLD1, and POLD2. The enzyme (PRMT7) is involved in regulation of the DNA repair machinery of the cell Homo sapiens