EC Number   |
General Information |
Reference  |
|---|
   3.4.24.B6 | metabolism |
TGF-beta signaling involved in amelogenesis is partially mediated by regulating the expression of MMP20 mRNA |
710860 |
| 3.4.24.B6 | physiological function |
MMP20 is an early enzyme, being expressed throughout the secretory stage and into earlier maturation stage of amelogenesis, an intense remodeling and degradation of the enamel matrix by proteases facilitates the enamel biomineralization, overview |
710860 |
| 3.4.24.B6 | physiological function |
MMP-20 is involved in the enamel formation and mineralization. The amelogenin degradation induced by MMP-20 is believed to be essential for the axial growth of enamel crystals MMP-20 activity is regulated by RUNX2, which is stimulated by BMP-2 or TGF-beta, and the odontogenic ameloblast-associated protein, ODAM, molecular mechanisms responsible for MMP-20 regulation, overview. Runx2 regulates ODAM expression, which in turn regulates MMP-20 expression and is recruited to the MMP-20 promoter. Increased MMP-20 expression accelerates amelogenin processing during enamel mineralization |
712555 |
| 3.4.24.B6 | physiological function |
the enzyme processes amelogenin to generate the major cleavage products that accumulate during the secretory stage of amelogenesis |
712586 |
| 3.4.24.B6 | physiological function |
the enamel protease MMP-20 cleaves amelogenin and is necessary for proper enamel formation. Matrix-mediated enamel biomineralization involves concurrent processes of enamel matrix protein degradation and hydroxyapatite maturation |
712587 |
| 3.4.24.B6 | more |
genetic defects in MMP20 are involved in the hypomaturation-type enamel defect |
712589 |
| 3.4.24.B6 | physiological function |
MMP20 is important in amelogenesis, like kallikrein 4, mutations in the kallikrein 4, KLK4, and enamelysin, MMP20, genes cause autosomal-recessive amelogenesis imperfecta |
712589 |
| 3.4.24.B6 | physiological function |
dental enamel is the product of ameloblasts and requires the secretion of the three matrix proteins amelogenin, ameloblastin, and enamelin, which are hydrolyzed by MMP-20 and kallikrein 4 and removed from the matrix. Enamel formation progresses through a secretory and a maturation stage, MMP-20 is expressed during the secretory and early-maturation stages |
712590 |
| 3.4.24.B6 | physiological function |
MMP20 is involved in kidney aging, the single nucleotide polymorphisms rs2245803 and rs1711437 in MMP20 are associated with kidney aging, overview |
713340 |
| 3.4.24.B6 | physiological function |
MMP-20 is a regulator that controls the functionality of amelogenin. The capacity of amelogenin to promote nucleation and crystal growth has been shown here to increase in proportion with the extent of its proteolytic degradation by means of MMP-20 |
718711 |
