BRENDA - Enzyme Database
show all sequences of 3.4.24.B6

The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20

Lee, H.K.; Lee, D.S.; Ryoo, H.M.; Park, J.T.; Park, S.J.; Bae, H.S.; Cho, M.I.; Park, J.C.; J. Cell. Biochem. 111, 755-767 (2010)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
real-time PCR MMP-20 expression analysis, overview
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
MMP-20 is synthesized and secreted by ameloblasts
Mus musculus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
required
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
amelogenin + H2O
Mus musculus
MMP-20 is involved in amelogenin processing and degradation
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
newborn C57/Bl6J mice
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
ameloblast
-
Mus musculus
-
enamel layer
-
Mus musculus
-
odontoblast
-
Mus musculus
-
tooth
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
amelogenin + H2O
-
712555
Mus musculus
?
-
-
-
?
amelogenin + H2O
MMP-20 is involved in amelogenin processing and degradation
712555
Mus musculus
?
-
-
-
?
casein + H2O
zymography
712555
Mus musculus
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
MMP-20
-
Mus musculus
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
22
-
assay at room temperature
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
real-time PCR MMP-20 expression analysis, overview
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
MMP-20 is synthesized and secreted by ameloblasts
Mus musculus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
required
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
amelogenin + H2O
Mus musculus
MMP-20 is involved in amelogenin processing and degradation
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
ameloblast
-
Mus musculus
-
enamel layer
-
Mus musculus
-
odontoblast
-
Mus musculus
-
tooth
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
amelogenin + H2O
-
712555
Mus musculus
?
-
-
-
?
amelogenin + H2O
MMP-20 is involved in amelogenin processing and degradation
712555
Mus musculus
?
-
-
-
?
casein + H2O
zymography
712555
Mus musculus
?
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
22
-
assay at room temperature
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Mus musculus
Expression
Organism
Commentary
Expression
Mus musculus
loss and siRNA-mediated silencing of Runx2 in ameloblast-lineage cells decreases ODAM expression, resulting in downregulation of MMP-20 expression
down
Mus musculus
increased expression of ODAM and Runx2 augments MMP-20 expression, and both TGF-beta1 and BMP-2 up-regulate Runx2 expression. TGF-beta1 promotes MMP-20 expression in ameloblasts
up
General Information
General Information
Commentary
Organism
physiological function
MMP-20 is involved in the enamel formation and mineralization. The amelogenin degradation induced by MMP-20 is believed to be essential for the axial growth of enamel crystals MMP-20 activity is regulated by RUNX2, which is stimulated by BMP-2 or TGF-beta, and the odontogenic ameloblast-associated protein, ODAM, molecular mechanisms responsible for MMP-20 regulation, overview. Runx2 regulates ODAM expression, which in turn regulates MMP-20 expression and is recruited to the MMP-20 promoter. Increased MMP-20 expression accelerates amelogenin processing during enamel mineralization
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
MMP-20 is involved in the enamel formation and mineralization. The amelogenin degradation induced by MMP-20 is believed to be essential for the axial growth of enamel crystals MMP-20 activity is regulated by RUNX2, which is stimulated by BMP-2 or TGF-beta, and the odontogenic ameloblast-associated protein, ODAM, molecular mechanisms responsible for MMP-20 regulation, overview. Runx2 regulates ODAM expression, which in turn regulates MMP-20 expression and is recruited to the MMP-20 promoter. Increased MMP-20 expression accelerates amelogenin processing during enamel mineralization
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
loss and siRNA-mediated silencing of Runx2 in ameloblast-lineage cells decreases ODAM expression, resulting in downregulation of MMP-20 expression
down
Mus musculus
increased expression of ODAM and Runx2 augments MMP-20 expression, and both TGF-beta1 and BMP-2 up-regulate Runx2 expression. TGF-beta1 promotes MMP-20 expression in ameloblasts
up
Other publictions for EC 3.4.24.B6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
754270
Yamazaki
Proteolysis by MMP20 prevents ...
Mus musculus
J. Dent. Res.
98
468-475
2019
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1
1
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753160
Gomes-Silva
Postradiation matrix metallop ...
Homo sapiens
Caries Res.
51
216-224
2017
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753705
Kim
Analyses of MMP20 missense mu ...
Homo sapiens
Front. Physiol.
8
229
2017
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752909
Prajapati
Matrix metalloproteinase-20 m ...
Mus musculus
Biomaterials
75
260-270
2016
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3
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1
1
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754269
Kwak
MMP20 Proteolysis of native a ...
Sus scrofa
J. Dent. Res.
95
1511-1517
2016
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754322
Ogbureke
Matrix metalloproteinase 20 c ...
Homo sapiens, Macaca fascicularis
J. Histochem. Cytochem.
64
623-636
2016
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4
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9
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9
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755434
Shin
Murine matrix metalloproteina ...
Mus musculus
Sci. Rep.
6
29492
2016
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1
1
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734404
Koli
Expression of matrix metallopr ...
Homo sapiens
J. Histochem. Cytochem.
63
524-533
2015
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1
1
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-
754268
Seymen
Novel MMP20 and KLK4 mutation ...
Homo sapiens
J. Dent. Res.
94
1063-1069
2015
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735135
Shin
Matrix metalloproteinase-20 ov ...
Mus musculus
PLoS ONE
9
e86774
2014
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3
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1
1
1
1
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733390
Khan
The proteolytic processing of ...
Homo sapiens
Biochim. Biophys. Acta
1830
2600-2607
2013
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1
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5
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2
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1
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5
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1
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5
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1
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5
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4
4
718711
Uskokovic
Hydrolysis of amelogenin by ma ...
Homo sapiens
Arch. Oral Biol.
56
1548-1559
2011
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1
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1
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1
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1
1
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719262
Bartlett
MMP20 cleaves E-cadherin and i ...
Mus musculus, Sus scrofa
Cells Tissues Organs
194
222-226
2011
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3
3
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720338
Yang
Amelogenin nanorods formation ...
Sus scrofa
J. Struct. Biol.
176
220-228
2011
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1
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2
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2
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1
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712555
Lee
The odontogenic ameloblast-ass ...
Mus musculus
J. Cell. Biochem.
111
755-767
2010
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1
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1
1
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1
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1
2
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712587
Sun
Apatite reduces amelogenin pro ...
Sus scrofa
J. Dent. Res.
89
344-348
2010
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1
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712589
Lee
MMP20 hemopexin domain mutatio ...
Homo sapiens
J. Dent. Res.
89
46-50
2010
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3
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2
2
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712590
Chun
Cleavage site specificity of M ...
Sus scrofa
J. Dent. Res.
89
785-790
2010
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1
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1
1
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3
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1
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5
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1
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1
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1
1
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710860
Gao
TGF-beta1 and TGFBR1 are expre ...
Mus musculus
Anat. Rec. (Hoboken)
292
885-890
2009
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4
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1
2
2
1
-
-
712586
Nagano
Mmp-20 and Klk4 cleavage site ...
Sus scrofa
J. Dent. Res.
88
823-828
2009
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1
1
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1
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2
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1
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1
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1
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4
-
1
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1
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1
1
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-
713340
Wheeler
Sequential use of transcriptio ...
Homo sapiens
PLoS Genet.
5
e1000685
2009
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1
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1
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2
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2
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Comparative properties of reco ...
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Reduced amelogenin-MMP20 inter ...
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Functions of KLK4 and MMP-20 i ...
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Arendt
Catalytic domain of MMP20 (ena ...
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Processing of ameloblastin by ...
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Turk
MMP-20 is predominately a toot ...
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Zhang
Fluoride down-regulates the ex ...
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2006
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Bartlett
A developmental comparison of ...
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Bourd-Boittin
Matrix metalloproteinase inhib ...
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Kim
MMP-20 mutation in autosomal r ...
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2005
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Bartlett
Decreased mineral content in M ...
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Bourd-Boittin
Immunolocalization of enamelys ...
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Terp
Structural differences of matr ...
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Stracke
Matrix metalloproteinases 19 a ...
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Ferreras
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Caterina
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Li
Activation of recombinant bovi ...
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Ryu
Characterization of recombinan ...
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Caterina
Isolation, characterization, a ...
Mus musculus
Genomics
62
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Llano
Identification and structural ...
Homo sapiens
Biochemistry
36
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