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Literature summary for 3.4.24.B6 extracted from

  • Sun, Z.; Carpiaux, W.; Fan, D.; Fan, Y.; Lakshminarayanan, R.; Moradian-Oldak, J.
    Apatite reduces amelogenin proteolysis by MMP-20 and KLK4 in vitro (2010), J. Dent. Res., 89, 344-348.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B6

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged MMP-20 Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
hydroxyapatite
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Sus scrofa 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amelogenin + H2O Sus scrofa amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged MMP-20 by metal affinity chromatography Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
enamel layer MMP-20 is expressed in the secretory stage Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amelogenin + H2O
-
 Sus scrofa ?
-
 ?
amelogenin + H2O amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
enamelysin
-
 Sus scrofa
MMP-20
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Sus scrofa

General Information

General Information Comment Organism
physiological function the enamel protease MMP-20 cleaves amelogenin and is necessary for proper enamel formation. Matrix-mediated enamel biomineralization involves concurrent processes of enamel matrix protein degradation and hydroxyapatite maturation Sus scrofa