EC Number   |
General Information |
Reference |
|---|
    1.14.17.1 | evolution |
DBH is a member of a small unique class of copper-containing hydroxylases that are found in eukaryotes, and all play a critical role in the biosynthesis of neurotransmitters and hormones. The other members of the family are the bifunctional enzyme peptidylglycine alpha-hydroxylating (and alpha-amidating) monooxygenase (PHM), monooxygenase X (DBH-like monooxygenase protein 1, MOXD1), and tyramine beta-monooxygease (TBH), which is the insect homologue of DBH |
746431 |
| 1.14.17.1 | physiological function |
DBH promoter contains at least one functional Egr1 motif, Egr1 may play a role in the physiological regulation of transcription of the DBH gene |
702956 |
| 1.14.17.1 | physiological function |
determinant role of Phox2a and Phox2b on the expression and function of DBH in vitro |
705254 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. The enzyme plays a critical role in catecholamine synthesis of neuroendocrine regulatory network, and is suggested to be involved in the immunoendocrine responses of invertebrate against bacterial challenge |
744949 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase (DBH) is a copper-containing monooxygenase enzyme that plays an important role in catecholamine synthesis of the neuroendocrine regulatory network. In shrimp, the biosynthesis of catecholamines, including dopamine and norepinephrine, is required for physiological and immunological responses against stress |
744950 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase (DBH) is the enzyme catalyzing the synthesis of noradrenaline from dopamine, it is stronger in the glomus cells of spontaneously hypertensive SHR/Izm rats than in those of Wistar Kyoto WKY/Izm rats |
-, 744191 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines |
746431 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. Effect of wild-type and mutant alpha-SYN on cAMP response element (CRE)-mediated regulation of the norepinephrine-synthesizing enzyme dopamine beta-hydroxylase (DBH): overexpression of wild-type or mutant human alpha-SYN interfers with CRE-mediated regulation of DBH transcription in norepinephrine-producing SK-N-BE(2) cells. Upon entering the nucleus, alpha-SYN interacts with the DBH promoter region encompassing the CRE, which interfered with forskolin-induced CREB binding to the CRE region. Mutant A53T alpha-SYN shows much higher tendency to nuclear translocation and interaction with the DBH promoter region encompassing the CRE than wild-type. CRE-mediated transcriptional regulation of tyrosine hydroxylase and enzyme DBH plays a crucial role in stress response |
744851 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. Effect of wild-type and mutant human alpha-SYN on cAMP response element (CRE)-mediated regulation of the norepinephrine-synthesizing enzyme dopamine beta-hydroxylase (DBH), stress-induced DBH regulation is modulated in the brains of A53T transgenic mice (A53T Tg). Overexpression of wild-type or mutant human alpha-SYN interfers with CRE-mediated regulation of DBH transcription in murine brains of A53T transgenic mice (A53T Tg). Upon entering the nucleus, alpha-SYN interacts with the DBH promoter region encompassing the CRE, which interfers with forskolin-induced CREB binding to the CRE region. Mutant A53T alpha-SYN shows much higher tendency to nuclear translocation and interaction with the DBH promoter region encompassing the CRE than wild-type |
744851 |
| 1.14.17.1 | physiological function |
dopamine beta-hydroxylase is a critical enzyme in the biosynthesis of catecholamines with a role in neuroendocrine regulation and in avian reproduction. Dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. The activity of DBH influences the levels of dopamine and the biosynthesis of norepinephrine and epinephrine. The enzyme is important in the nervous system |
744598 |
