EC Number   |
General Information  |
Reference |
|---|
    1.14.17.1 | evolution |
DBH is a member of a small unique class of copper-containing hydroxylases that are found in eukaryotes, and all play a critical role in the biosynthesis of neurotransmitters and hormones. The other members of the family are the bifunctional enzyme peptidylglycine alpha-hydroxylating (and alpha-amidating) monooxygenase (PHM), monooxygenase X (DBH-like monooxygenase protein 1, MOXD1), and tyramine beta-monooxygease (TBH), which is the insect homologue of DBH |
746431 |
| 1.14.17.1 | evolution |
the enzyme belongs to the copper type II, ascorbate-dependent monooxygenases |
744949, 744950 |
| 1.14.17.1 | malfunction |
dopamine-beta-hydroxylase knockout mice are more sensitive to stress but survive a single 2 h restraint stress in a tube. Disruption of the DBH gene blocks the stress-induced elevation of tyrosine hydroxylase mRNA levels in adrenal medulla but increases phenylethanolamine N-methyltransferase gene expression in both adrenal medulla and stellate ganglia |
701704 |
| 1.14.17.1 | malfunction |
enzyme activity and norepinephrine level in shrimps downregulated by LvDBH-dsRNA are reduced, the treated animals show increased susceptibility to Vibrio alginolyticus infection, significantly lower total hemocyte count, phagocytic activity, clearance efficiency, and resistance to Vibrio alginolyticus infection are observed in shrimp that received LvDBH-dsRNA at 3 days post injection compared to those injected with diethyl pyrocarbonate-water or non-targeting gene-dsRNA |
744950 |
| 1.14.17.1 | malfunction |
enzyme LvDBH inhibited or silenced in haemocytes by disulfiram and LvDBH-dsRNA, repectively, results in impaired synthesis of norepinephrine from dopamine in hemolymph |
744949 |
| 1.14.17.1 | malfunction |
genotype-phenotype correlations. Mutant L317P shows secretory deficiency and is localized in the endoplasmic reticulum |
745892 |
| 1.14.17.1 | malfunction |
in the GRDBHCre mice, glucocorticoid receptor (GR) immunoreactivity is lost in chromaffin cells but is unaltered in the cortex, which leads to the loss of the A-synthesizing enzyme phenylethanolamine-N-methyl-transferase (PNMT). GRDBHCre mutants are viable and fertile and do not appear different from control littermates. Degeneration of the adrenal medulla in young GRDBHCre mutants |
703462 |
| 1.14.17.1 | malfunction |
no major role of the -1021C>T polymorphism or the gene itself in the development of cocaine addiction in a Brazilian sample of 689 cocaine addicts and 832 healthy controls, even after correction for sex age, education and population stratification |
701996 |
| 1.14.17.1 | more |
enzyme structure analysis, detailed overview |
746431 |
| 1.14.17.1 | more |
enzyme structure-function relationship, overview |
745892 |
