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Literature summary for 1.14.17.1 extracted from

  • Cheng, W.; Ka, Y.W.; Chang, C.C.
    Dopamine beta-hydroxylase participate in the immunoendocrine responses of hypothermal stressed white shrimp, Litopenaeus vannamei (2016), Fish Shellfish Immunol., 59, 166-178 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene dbh, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis and tree, quantitative real-time PCR enzyme expression analysis Penaeus vannamei

Protein Variants

Protein Variants Comment Organism
additional information LvDBH expression is silenced in thoracic ganglia, haemocytes and hepatopancreas of shrimp by treatment with LvDBH-dsRNA for 3 days, a decrease of DBH contents in haemocytes accompanied by decreased levels of norepinephrine and dopamine in hemolymph are observed Penaeus vannamei

Inhibitors

Inhibitors Comment Organism Structure
Disulfiram pharmaceutical inhibition of enzyme DBH Penaeus vannamei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dopamine + ascorbate + O2 Penaeus vannamei
-
noradrenaline + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Penaeus vannamei A0A1I9LDK0
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation Penaeus vannamei

Source Tissue

Source Tissue Comment Organism Textmining
hemocyte
-
Penaeus vannamei
-
hepatopancreas
-
Penaeus vannamei
-
additional information determination of tissue distribution of enzyme expression by quantitative real-time PCR enzyme expression analysis Penaeus vannamei
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thoracic ganglion
-
Penaeus vannamei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + ascorbate + O2
-
Penaeus vannamei noradrenaline + dehydroascorbate + H2O
-
?

Subunits

Subunits Comment Organism
More the enzyme contains a DOMON domain, a Cu2_monooxygen domain, and three glycosylation sites Penaeus vannamei

Synonyms

Synonyms Comment Organism
DBH
-
Penaeus vannamei
dopamine beta-hydroxylase
-
Penaeus vannamei
LvDBH
-
Penaeus vannamei

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
Penaeus vannamei

Expression

Organism Comment Expression
Penaeus vannamei LvDBH expression is silenced in thoracic ganglia, haemocytes and hepatopancreas of shrimp by treatment with LvDBH-dsRNA for 3 days, a decrease of DBH contents in haemocytes accompanied by decreased levels of norepinephrine and dopamine in hemolymph are observed. LvDBH expressions in thoracic ganglia, haemocytes, and hepatopancreas of shrimp transferred from 28°C to 20°C for 30 min are significant higher than those held at 28°C, hypothermal stress reduces the expression of LvDBH down

General Information

General Information Comment Organism
evolution the enzyme belongs to the copper type II, ascorbate-dependent monooxygenases Penaeus vannamei
malfunction enzyme LvDBH inhibited or silenced in haemocytes by disulfiram and LvDBH-dsRNA, repectively, results in impaired synthesis of norepinephrine from dopamine in hemolymph Penaeus vannamei
physiological function dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the biosynthesis of catecholamines. The enzyme plays a critical role in catecholamine synthesis of neuroendocrine regulatory network, and is suggested to be involved in the immunoendocrine responses of invertebrate against bacterial challenge Penaeus vannamei