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Literature summary for 1.14.17.1 extracted from

  • Cheng, W.; Ka, Y.W.; Chang, C.C.
    Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei (2017), Fish Shellfish Immunol., 68, 92-101 .
    View publication on PubMed
Search for more literature for 1.14.17.1

Inhibitors

Inhibitors Comment Organism Structure
Disulfiram pharmaceutical inhibition of enzyme DBH Penaeus vannamei

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ enzyme-bound, required for activity Penaeus vannamei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dopamine + ascorbate + O2 Penaeus vannamei
-
 noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Penaeus vannamei A0A1I9LDK0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hemocyte
-
 Penaeus vannamei
-
hepatopancreas
-
 Penaeus vannamei
-
thoracic ganglion
-
 Penaeus vannamei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + ascorbate + O2
-
 Penaeus vannamei noradrenaline + dehydroascorbate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
DBH
-
 Penaeus vannamei
dopamine beta-hydroxylase
-
 Penaeus vannamei

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
 Penaeus vannamei

Expression

Organism Comment Expression
Penaeus vannamei enzyme downregulation by LvDBH-dsRNA down

General Information

General Information Comment Organism
evolution the enzyme belongs to the copper type II, ascorbate-dependent monooxygenases Penaeus vannamei
malfunction enzyme activity and norepinephrine level in shrimps downregulated by LvDBH-dsRNA are reduced, the treated animals show increased susceptibility to Vibrio alginolyticus infection, significantly lower total hemocyte count, phagocytic activity, clearance efficiency, and resistance to Vibrio alginolyticus infection are observed in shrimp that received LvDBH-dsRNA at 3 days post injection compared to those injected with diethyl pyrocarbonate-water or non-targeting gene-dsRNA Penaeus vannamei
physiological function dopamine beta-hydroxylase (DBH) is a copper-containing monooxygenase enzyme that plays an important role in catecholamine synthesis of the neuroendocrine regulatory network. In shrimp, the biosynthesis of catecholamines, including dopamine and norepinephrine, is required for physiological and immunological responses against stress Penaeus vannamei