EC Number |
Posttranslational Modification |
Reference |
---|
5.6.1.6 | glycoprotein |
- |
210426, 210430, 210431, 695466, 750504 |
5.6.1.6 | glycoprotein |
enzyme CFTR core glycosylation occurs in the endoplasmic reticulum |
734305 |
5.6.1.6 | glycoprotein |
glycosylation analysis using endoglycosidase H and peptide N-glycosidase F digestion |
700093 |
5.6.1.6 | glycoprotein |
the enzyme is synthesized in the ER and co-translationally undergoes core glycosylation as an initial step in CFTR processing. During CFTR traffic through the Golgi complex its two N-linked oligosaccharide chains are converted from high mannose to complex structures prior to its trafficking to the plasma membrane |
210435 |
5.6.1.6 | glycoprotein |
the mature enzyme is fully glycosylated |
698823 |
5.6.1.6 | phosphoprotein |
- |
700296, 749935, 750504 |
5.6.1.6 | phosphoprotein |
CFTR gating is regulated by protein kinase A-mediated phosphorylation and by interaction with ATP |
700618 |
5.6.1.6 | phosphoprotein |
control of CFTR channel activity is modulated by the phosphorylation of the R domain by protein kinase A, which allows the regulation of gating by ATP binding at the NBD1/NBD2 interface |
698802 |
5.6.1.6 | phosphoprotein |
enzyme activation requires phosphorylation by protein kinase A |
750278 |
5.6.1.6 | phosphoprotein |
enzyme gets activated by cAMP-dependent phosphorylation |
712581 |