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Information on EC 5.6.1.6 - channel-conductance-controlling ATPase

for references in articles please use BRENDA:EC5.6.1.6
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IUBMB Comments
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
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Word Map
  • 5.6.1.6
  • camp
  • gate
  • gating
  • forskolin
  • deltaf508
  • na+
  • camp-dependent
  • transepithelial
  • nasal
  • bronchial
  • short-circuit
  • nucleotide-binding
  • patch-clamp
  • mucus
  • deferens
  • camp-activated
  • infertility
  • glibenclamide
  • electrolyte
  • bicarbonate
  • ussing
  • non-cf
  • cotransporter
  • mucociliary
  • calu-3
  • single-channel
  • camp-regulated
  • rectify
  • camp-stimulated
  • amiloride
  • trypsinogen
  • submucosal
  • ibmx
  • inside-out
  • electrogenic
  • amiloride-sensitive
  • current-voltage
  • forskolin-stimulated
  • cell-attached
  • azoospermia
  • bumetanide
  • outwardly
  • bronchiectasis
  • camp-mediated
  • guanylin
  • ileus
  • adpkd
  • meconium
  • spink1
  • voltage-independent
  • medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
closed Cl- channel
=
+
+
open Cl- channel
Synonyms
ABCC7, CFTR, CFTR channel, CFTR Cl- channel, cystic fibrosis conductance regulator, cystic fibrosis transmembrane conductance regulator, cystic fibrosis transmembrane regulator, cystic-fibrosis membrane-conductance protein, EBCR, epithelial basolateral chloride conductance regulator, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel
show the reaction diagram
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