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Information on EC 5.6.1.6 - channel-conductance-controlling ATPase

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IUBMB Comments
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The enzyme is also involved in the functioning of other transmembrane channels.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
closed Cl- channel
=
+
+
open Cl- channel
Synonyms
ABCC7, CFTR, CFTR channel, CFTR Cl- channel, cystic fibrosis conductance regulator, cystic fibrosis transmembrane conductance regulator, cystic fibrosis transmembrane regulator, cystic-fibrosis membrane-conductance protein, EBCR, epithelial basolateral chloride conductance regulator, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel
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