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EC Number	Metals/Ions	Commentary	Reference
1.1.5.3	Iron	contains 1 gatom of acid liberatable iron per 310000 g of protein	287802
1.1.5.3	Iron	contains iron	287806, 287812
1.1.5.3	K+	20 mM NaCl or KCl required for maximal activity	287807
1.1.5.3	Na+	20 mM NaCl or KCl required for maximal activity	287807
1.1.5.3	Iron	contains 1 nmol non-heme iron per mg of protein	287809
1.1.5.3	Iron	contains 2 mol of non-heme iron per dimer	287817
1.1.5.3	Ca2+	-	287818
1.1.5.3	Ca2+	0.7 mM required for half-maximal activation of activity with 2,6-dichlorophenolindophenol in euthyroid rats, 0.002 mM required for half-maximal activation of activity with vitamin K3 in euthyroid rats. Ca2+ causes an alteration in the conformation of the enzyme	287821
1.1.5.3	Mg2+	activates	287821, 740095
1.1.5.3	Ca2+	activates	287829, 287831, 740095

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Release 2023.1 (January 2023)