EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.65 | cysteine |
the enzyme is completely dependent on preactivation with cysteine |
647745 |
| 3.4.22.65 | dithiothreitol |
- |
695433 |
| 3.4.22.65 | more |
Der p 1 dose-dependently increase the production of IL-6 and IL-8, can be blocked by heat treatment and cell desquamation |
664637 |
| 3.4.22.65 | more |
Der p 1 induce the release of IL-1beta, IL-6, IL-10, tumor necrosis factor-alpha and granulocyte macrophage colony-stimulating factor from eosinophils, surface expression of CD18 and ICAM-1, can activate NK-KB, AP-1 activity and p38 MAPK in BEAS-2B cells and eosinophils alone and in co-culture |
665206 |
| 3.4.22.65 | more |
Der p 1 induces chemokine production (CXCL8, CXCL10, CCL2, CCL5 and CCL20) by bronchial epithelial cells BEAS-2B and BECs from nonatopic controls through protease-activated receptor (PAR)-2 cleavage |
665291 |
| 3.4.22.65 | more |
Der p 1 stimulates the expression of Interleukin-8 in human pulmonary epithelial cells via the ERK1/2 signaling pathway |
665740 |
