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Literature summary for 3.4.22.65 extracted from

  • Kauffman Henk , K.H.; Tamm Michae, T.M.; Timmerman J. Andre , T.J.; Borger Pete, B.P.
    House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms (2006), Clin. Mol. Allergy, 4, 5-5.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information Der p 1 dose-dependently increase the production of IL-6 and IL-8, can be blocked by heat treatment and cell desquamation Dermatophagoides pteronyssinus

Application

Application Comment Organism
medicine induces biological responses in a human airway-derived epithelial cell line Dermatophagoides pteronyssinus

Cloned(Commentary)

Cloned (Comment) Organism
recDer p 1 Dermatophagoides pteronyssinus

Inhibitors

Inhibitors Comment Organism Structure
E-64 trans-epoxysuccinyl L-leucylamido (4-guanidine) butane, 0.01 mM, complete inhibition of interleukine production in A549 epithelial cells Dermatophagoides pteronyssinus

Organism

Organism UniProt Comment Textmining
Dermatophagoides pteronyssinus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography Dermatophagoides pteronyssinus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information house dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms Dermatophagoides pteronyssinus ?
-
 ?

Synonyms

Synonyms Comment Organism
allergen Der p 1
-
 Dermatophagoides pteronyssinus
Der p 1
-
 Dermatophagoides pteronyssinus
house dust mite allergens HDM Dermatophagoides pteronyssinus