EC Number   |
Activating Compound |
Reference |
|---|
    5.3.99.3 | dithiothreitol |
leads to dissociation of the bound heme which is hindered by imidazole |
727942 |
| 5.3.99.3 | epigallocatechin gallate |
enhances COX-2 and isoform mPGES-1 gene expression and production of prostaglandin E2. Induction of mPGES-1 is mediated by active ERK1/2MAP kinases and early growth response gene 1 |
678094 |
| 5.3.99.3 | glutathione |
- |
660669, 660677, 662071, 662768, 663277, 690714, 748542 |
| 5.3.99.3 | glutathione |
the N-terminal domain contains the GSH-binding site (G-site) |
726884 |
| 5.3.99.3 | GSH |
2 mM required for maximal activity of IgG1(hei-7)-reactive protein |
3126 |
| 5.3.99.3 | GSH |
activates |
3127 |
| 5.3.99.3 | GSH |
concentrations below 0.5 mM are required for maximal activity of IgG1(hei-26)-reactive protein |
3126 |
| 5.3.99.3 | GSH |
dependent on |
3126, 3128, 3129 |
| 5.3.99.3 | GSH |
mPGES2 has a GSH-binding motif, the GSH molecule binds at the predicted amino acid residues 148VPxL to 164DSxxI. GSH is essential for heme binding to isozyme mPGES2, structures of GSH-heme complex-binding cavity in isozyme mPGES2, overview |
727942 |
| 5.3.99.3 | GSH |
the enzyme activity is increased in the presence of reduced glutathione |
747606 |
