EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.55 | RAIDD |
caspase-2 activation is dependent on the adaptor protein RAIDD |
731274 |
| 3.4.22.55 | silibinin |
caspase-2 and caspase-8 can activate each other in response to silibinin |
664533 |
| 3.4.22.55 | palmitate |
caspase-2 is activated by an overabundance of saturated long-chain fatty acids like palmitate. Inhibition of amino acid transamination by 10 mM aminooxyacetate blocks caspase activation |
732099 |
| 3.4.22.55 | ATM/ATR |
caspase-2 is activated by ATM/ATR independently of p53 when Chk1 activity is repressed |
717458 |
| 3.4.22.55 | more |
caspase-2 is activated by dimerization |
717458 |
| 3.4.22.55 | more |
caspase-2 is activated by proximity-induced oligomerization and trans-cleavage in vitro. Caspase-2 activation is possibly also mediated by caspase-8 in the death-inducing signaling complex |
732220 |
| 3.4.22.55 | more |
caspase-2 is rapidly activated by nerve growth factor deprivation |
731274 |
| 3.4.22.55 | more |
etoposide, staurosporine, pacritaxel and cyclohexamide treatment promotes exon 9-inclusion, increasing the ratio of caspase-2S to caspase-2L |
665952 |
| 3.4.22.55 | more |
genotoxic stress |
665588 |
| 3.4.22.55 | more |
heat shock, UV irradiation and anti-Fas treatment activate caspase-2 |
666419 |
