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Literature summary for 3.4.22.55 extracted from

  • Fava, L.; Bock, F.; Geley, S.; Villunger, A.
    Caspase-2 at a glance (2012), J. Cell Sci., 125, 5911-5915.
    View publication on PubMed
Search for more literature for 3.4.22.55

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-2 is activated by proximity-induced oligomerization and trans-cleavage in vitro. Caspase-2 activation is possibly also mediated by caspase-8 in the death-inducing signaling complex Mus musculus
PIDD protein
-
 Mus musculus
protein phosphatase 1
-
 Mus musculus
RAIDD protein
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cyclin-dependent kinase 1
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BID + H2O Mus musculus
-
 ?
-
 ?
caspase-2 + H2O Mus musculus self-cleavage for activation ?
-
 ?
CERT + H2O Mus musculus
-
 ?
-
 ?
DELTANp63 + H2O Mus musculus
-
 ?
-
 ?
elF4B + H2O Mus musculus
-
 ?
-
 ?
golgin-160 + H2O Mus musculus
-
 ?
-
 ?
HDAC4 + H2O Mus musculus
-
 ?
-
 ?
huntingtin + H2O Mus musculus
-
 ?
-
 ?
ICAD + H2O Mus musculus
-
 ?
-
 ?
MDM2 + H2O Mus musculus
-
 ?
-
 ?
additional information Mus musculus caspase-2 is a substrate for caspase-8 and caspase-3 ?
-
 ?
pakin + H2O Mus musculus
-
 ?
-
 ?
PARP + H2O Mus musculus
-
 ?
-
 ?
protein kinase Cdelta + H2O Mus musculus
-
 ?
-
 ?
ROCK1 + H2O Mus musculus
-
 ?
-
 ?
ROCK2 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P29594
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Ser-340 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BID + H2O
-
 Mus musculus ?
-
 ?
caspase-2 + H2O self-cleavage for activation Mus musculus ?
-
 ?
CERT + H2O
-
 Mus musculus ?
-
 ?
DELTANp63 + H2O
-
 Mus musculus ?
-
 ?
elF4B + H2O
-
 Mus musculus ?
-
 ?
golgin-160 + H2O
-
 Mus musculus ?
-
 ?
HDAC4 + H2O
-
 Mus musculus ?
-
 ?
huntingtin + H2O
-
 Mus musculus ?
-
 ?
ICAD + H2O
-
 Mus musculus ?
-
 ?
MDM2 + H2O
-
 Mus musculus ?
-
 ?
additional information caspase-2 is a substrate for caspase-8 and caspase-3 Mus musculus ?
-
 ?
pakin + H2O
-
 Mus musculus ?
-
 ?
PARP + H2O
-
 Mus musculus ?
-
 ?
protein kinase Cdelta + H2O
-
 Mus musculus ?
-
 ?
ROCK1 + H2O
-
 Mus musculus ?
-
 ?
ROCK2 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ICH-1 formerly Mus musculus
NEDD-2 formerly Mus musculus

General Information

General Information Comment Organism
malfunction cells lacking caspase-2 are protected from cell death induced by Staphylococcus aureus alpha-toxin Mus musculus
physiological function caspase-2 is implicated in the regulation of cell death that is induced by metabolic imbalance, DNA damage, endoplasmic reticulum (ER) stress, mitotic catastrophe and others. Caspase-2 is implicated in the induction of cell death by pathogenic bacteria, such as Brucella, Staphylococcus aureus and Salmonella. Caspase-2 is controlling aging and cell death in response to DNA damage. The enzyme is also linked to cell death that is induced by aberrant mitosis in cancer cells that transiently arrest in prometaphase after cell fusion. Caspase 2 is crucial for oocyte apoptosis Mus musculus