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Literature summary for 3.4.22.55 extracted from

  • Jean, Y.Y.; Ribe, E.M.; Pero, M.E.; Moskalenko, M.; Iqbal, Z.; Marks, L.J.; Greene, L.A.; Troy, C.M.
    Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death (2013), Biochem. J., 455, 15-25.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
amyloid beta1-42 the levels of activated caspase-2 in cultured hippocampal neurons significantly increase within 30 min of treatment with 0.003 mM amyloid beta1-42 Rattus norvegicus
additional information caspase-2 is rapidly activated by nerve growth factor deprivation Rattus norvegicus
RAIDD caspase-2 activation is dependent on the adaptor protein RAIDD Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
biotinylated VAD-fluoromethylketone irreversible pan-caspase inhibitor Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 45000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CUX1 + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P55215
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CUX1 + H2O
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
Casp2
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme is essential for c-Jun transcriptional activation and Bim induction in in neurons subjected to apoptotic stimuli Rattus norvegicus