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Information on EC 4.4.1.28 - L-cysteine desulfidase

for references in articles please use BRENDA:EC4.4.1.28
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IUBMB Comments
The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine gamma-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine gamma-lyase).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
aecD, At5g28030, CDL, CFL1_01513, cystalysin, DES1, L-cysteine desulfhydrase, les, MJ1025, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
2-aminoprop-2-enoate = 2-iminopropanoate
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2-iminopropanoate + H2O = pyruvate + NH3
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L-cysteine + H2O = sulfide + NH3 + pyruvate
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L-cysteine = 2-aminoprop-2-enoate + sulfide
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