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Information on EC 3.6.1.60 - diadenosine hexaphosphate hydrolase (AMP-forming)

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IUBMB Comments
A divalent cation is essential for activity. Mn2+ (2--6 mM) is most effective. The enzyme controls intracellular levels of P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5'-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides.
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The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms
nudt11, nudt10, haps1, haps2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP
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P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-pentaphosphate + AMP
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