Ligand adenosine 5'-tetraphosphate

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Basic Ligand Information

Molecular Structure
Picture of adenosine 5'-tetraphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H17N5O16P4
adenosine 5'-tetraphosphate
WWMWAMFHUSTZTA-KQYNXXCUSA-N
Synonyms:
adenosine-5'-tetraphosphate, adenosine tetraphosphate, Ap4, p4A
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP
show the reaction diagram
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diadenosine 5',5''-P1,P5-pentaposphate + H2O = ATP + ADP + AMP + adenosine 5'-tetraphosphate
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P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-tetraphosphate + ADP
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-

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine 5'-tetraphosphate + Photinus luciferin = oxidized Photinus luciferin + CO2 + H2O + AMP + diphosphate + hv
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UDP-glucose + adenosine 5'-tetraphosphate = D-glucose-1-phosphate + adenosyl-5'-pentaphospho-5'-uridine
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adenosine 5'-tetraphosphate + H2O = inosine 5'-tetraphosphate + NH3
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adenosine 5'-tetraphosphate + H2O = ATP + phosphate
show the reaction diagram
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adenosine 5'-tetraphosphate + H2O = ATP + phosphate
show the reaction diagram
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p4A + H2O = ATP + phosphate
show the reaction diagram
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Ap4 + H2O = ?
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adenosine 5'-tetraphosphate + H2O = adenosine 5'-monophosphate + phosphate
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adenosine tetraphosphate + H2O = ?
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + phosphate = adenosine 5'-tetraphosphate + H2O
show the reaction diagram
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P1,P6-di(adenosine-5')hexaphosphate + H2O = ADP + adenosine 5'-tetraphosphate
show the reaction diagram
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P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate
show the reaction diagram
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P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate
show the reaction diagram
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P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP
show the reaction diagram
-
-
P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-tetraphosphate + ADP
show the reaction diagram
-
-
ATP + tripolyphosphate = adenosine 5'-tetraphosphate
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4-coumarate + MgATP2- + tripolyphosphate = adenosine 5'-tetraphosphate + ?
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ATP + ATP = adenosine 5'-tetraphosphate + ADP
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ATP + UDP-N-acetylmuramate-L-alanine = adenosine 5'-tetraphosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, slight activation
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Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
723
-
-
0.24
-
in the presence of 10 mM Mg2+, at pH 9.0 and 26°C

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.004
-
in the presence of 10 mM Mg2+, at pH 9.0 and 26°C
0.064
-
reverse reaction, M293P/K320L mutant enzyme, pH 7.0, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00001
-
pH 7.8, 25°C

References & Links

Links to other databases for adenosine 5'-tetraphosphate

ChEBI
PubChem
ChEBI
PubChem