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Information on EC 2.6.1.97 - archaeosine synthase

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.97 archaeosine synthase
IUBMB Comments
In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase . The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.
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Word Map
  • 2.6.1.97
  • ligases
  • ubiquitin-protein
  • nedd4-2
  • cell-expressed
  • liddle
  • 4-like
  • nedd4-mediated
  • amiloride-sensitive
  • nedd4-like
  • ndfip1
  • gammaenac
  • nedd4-binding
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
7-cyano-7-carbaguanine15 in tRNA
+
=
+
archaeine15 in tRNA
Synonyms
tgta2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
show the reaction diagram
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-
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-
PATHWAY SOURCE
PATHWAYS
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