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Information on EC 2.5.1.74 - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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IUBMB Comments
This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein , with the C-terminus located in the periplasm . It is highly specific for DHNA but not for a specific length of the prenyl chain .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
1,4-dihydroxy-2-naphthoate octaprenyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2
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