Cloned (Comment) | Organism |
---|---|
gene McMenA, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative RT-PCR enzyme expression analysis | Mylabris cichorii |
Protein Variants | Comment | Organism |
---|---|---|
additional information | specific double-strand RNA (dsRNA) of McMenA leads to a significant reduction of McMenA mRNA levels | Mylabris cichorii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mylabris cichorii | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mylabris cichorii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37900 | - |
- |
Mylabris cichorii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate | Mylabris cichorii | - |
a demethylmenaquinol + diphosphate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mylabris cichorii | A0A0U1XZ37 | gene McMenA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
female accessory gland | lowest expression level of MenA | Mylabris cichorii | - |
foregut | - |
Mylabris cichorii | - |
hindgut | - |
Mylabris cichorii | - |
male accessory gland | lowest expression level of MenA | Mylabris cichorii | - |
midgut | - |
Mylabris cichorii | - |
additional information | highest expression of McMenA occur during 22-25 days in the sex-separate breeding males, while the lowest expression occur in females at the same time | Mylabris cichorii | - |
testis | highest expression level of MenA | Mylabris cichorii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate | - |
Mylabris cichorii | a demethylmenaquinol + diphosphate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 37900, about, sequence calculation | Mylabris cichorii |
Synonyms | Comment | Organism |
---|---|---|
1,4-dihydroxy-2-naphthoate octaprenyltransferase | - |
Mylabris cichorii |
MenA | - |
Mylabris cichorii |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mylabris cichorii | sequence calculation | - |
8.94 |
General Information | Comment | Organism |
---|---|---|
additional information | the aspartate rich motif N/DDxxD representesbinding sites for prenyl diphosphate via a Mg2+ ion | Mylabris cichorii |
physiological function | the enzyme catalyzes the conversion of 1,4-dihydroxy-2-naphthoate to demethylmenaquinone. This step, prior to the methylation of demethylmenaquinone to menaquinone (vitamin K2), is a key reaction in menaquinone biosynthesis. Menaquinone is an obligatory component of the electron transfer pathway. Enzyme McMenA plays a role in the biosynthesis of cantharidin and ATP in Mylabris cichorii | Mylabris cichorii |