Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.74 extracted from

  • Liao, Y.F.; Wang, Y.; Huang, Y.; Zha, S.F.; Liu, J.J.; Wang, Z.K.; Yin, Y.P.; Liao, Y.F.; Wang, Y.
    Isolation and functional analysis of McMenA, a gene encoding a 1,4-dihydroxy-2-naphthoate octaprenyltransferase in Mylabris cichorii (2015), Arch. Insect Biochem. Physiol., 89, 127-137.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene McMenA, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative RT-PCR enzyme expression analysis Mylabris cichorii

Protein Variants

Protein Variants Comment Organism
additional information specific double-strand RNA (dsRNA) of McMenA leads to a significant reduction of McMenA mRNA levels Mylabris cichorii

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mylabris cichorii 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mylabris cichorii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37900
-
-
Mylabris cichorii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate Mylabris cichorii
-
a demethylmenaquinol + diphosphate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mylabris cichorii A0A0U1XZ37 gene McMenA
-

Source Tissue

Source Tissue Comment Organism Textmining
female accessory gland lowest expression level of MenA Mylabris cichorii
-
foregut
-
Mylabris cichorii
-
hindgut
-
Mylabris cichorii
-
male accessory gland lowest expression level of MenA Mylabris cichorii
-
midgut
-
Mylabris cichorii
-
additional information highest expression of McMenA occur during 22-25 days in the sex-separate breeding males, while the lowest expression occur in females at the same time Mylabris cichorii
-
testis highest expression level of MenA Mylabris cichorii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate
-
Mylabris cichorii a demethylmenaquinol + diphosphate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 37900, about, sequence calculation Mylabris cichorii

Synonyms

Synonyms Comment Organism
1,4-dihydroxy-2-naphthoate octaprenyltransferase
-
Mylabris cichorii
MenA
-
Mylabris cichorii

pI Value

Organism Comment pI Value Maximum pI Value
Mylabris cichorii sequence calculation
-
8.94

General Information

General Information Comment Organism
additional information the aspartate rich motif N/DDxxD representesbinding sites for prenyl diphosphate via a Mg2+ ion Mylabris cichorii
physiological function the enzyme catalyzes the conversion of 1,4-dihydroxy-2-naphthoate to demethylmenaquinone. This step, prior to the methylation of demethylmenaquinone to menaquinone (vitamin K2), is a key reaction in menaquinone biosynthesis. Menaquinone is an obligatory component of the electron transfer pathway. Enzyme McMenA plays a role in the biosynthesis of cantharidin and ATP in Mylabris cichorii Mylabris cichorii