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Information on EC 2.4.99.20 - 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

for references in articles please use BRENDA:EC2.4.99.20
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IUBMB Comments
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
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The enzyme appears in viruses and cellular organisms
Synonyms
adp-ribosyl cyclase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate
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NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide
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NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide
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PATHWAY SOURCE
PATHWAYS
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