KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5 | - |
nicotinate | pH 5, 22°C | Homo sapiens | |
5 | - |
nicotinate | pH 5, 22°C | Aplysia californica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aplysia californica | P29241 | bifunctional enzyme that can synthesize cADPR from NAD1 as well as hydrolyze cADPR to ADP-ribose | - |
Homo sapiens | P28907 | bifunctional enzyme that can synthesize cADPR from NAD1 as well as hydrolyze cADPR to ADP-ribose | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-phospho-cyclic ADP-ribose + nicotinate | - |
Homo sapiens | nicotinate-adenine dinucleotide phosphate | - |
? | |
2'-phospho-cyclic ADP-ribose + nicotinate | - |
Aplysia californica | nicotinate-adenine dinucleotide phosphate | - |
? | |
additional information | in the absence of nicotinic acid or at neutral pH, isoform CD38 converts NADP+ to ADP-ribose 2'-phosphate, which is the hydrolysis product of cyclic ADPribose 2'-phosphate, reaction of EC 3.2.2.6 | Aplysia californica | ? | - |
? | |
additional information | the switch of the catalysis to the exchange reaction requires acidic pH and nicotinic acid. In the absence of nicotinic acid or at neutral pH, the cyclase converts NADP+ to cyclic ADP-ribose 2'-phosphate | Homo sapiens | ? | - |
? | |
NADP+ | - |
Homo sapiens | 2'-phospho-cyclic ADP-ribose + nicotinamide | - |
? | |
NADP+ | - |
Aplysia californica | 2'-phospho-cyclic ADP-ribose + nicotinamide | - |
? |