Literature summary for 2.4.99.20 extracted from

Chini, E.N.; Chini, C.C.; Kato, I.; Takasawa, S.; Okamoto, H.
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues (2002), Biochem. J., 362, 125-130.

Search for more literature for 2.4.99.20

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	0.13 nM/min*mg	Mus musculus	-	-
mitochondrion	0.2 nM/min*mg	Mus musculus	5739	-
nucleus	0.4 nM/min*mg	Mus musculus	5634	-
plasma membrane	1.6 nM/min*mg	Mus musculus	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADP+ + nicotinate	Rattus norvegicus	this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?
NADP+ + nicotinate	Mus musculus	this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	Q64244	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate	reaction 1 b	Rattus norvegicus	a
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide	overall reaction. The multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Rattus norvegicus	a
NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide	reaction 1a	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
brain	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
additional information	very low activity in kidney cortex and skeletal muscles	Rattus norvegicus	-
myocardium	-	Rattus norvegicus	-
spleen	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00000013	-	37°C, pH 7.2, microsome from CD38(+/+) wild-type mouse brain	Mus musculus
0.0000002	-	37°C, pH 7.2, mitochondria from CD38(+/+) wild-type mouse brain	Mus musculus
0.0000016	-	37°C, pH 7.2, plasma membrane from CD38(+/+) wild-type mouse brain	Mus musculus
0.4	-	37°C, pH 7.2, nucleus from CD38(+/+) wild-type mouse brain	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2'-phospho-cyclic ADP-ribose + nicotinate	-	Mus musculus	nicotinate-adenine dinucleotide phosphate	-	?
2'-phospho-cyclic ADP-ribose + nicotinate	-	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate	-	?
NADP+ + nicotinate	-	Mus musculus	nicotinate-adenine dinucleotide phosphate + nicotinamide	nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+	?
NADP+ + nicotinate	-	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate + nicotinamide	nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+	?
NADP+ + nicotinate	this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?
NADP+ + nicotinate	this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Mus musculus	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?

Synonyms

Synonyms	Comment	Organism
BST1	-	Mus musculus
BST1	-	Rattus norvegicus
CD38	-	Mus musculus
CD38	-	Rattus norvegicus
diphosphopyridine nucleosidase	ambiguous	Mus musculus
diphosphopyridine nucleosidase	ambiguous	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Mus musculus

General Information

General Information	Comment	Organism
malfunction	generation of CD38(-/-) knockout mice of determine the role of this enzyme	Mus musculus
physiological function	the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Mus musculus
physiological function	the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Rattus norvegicus

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Release 2023.1 (January 2023)