BRENDA - Enzyme Database show
show all sequences of 2.4.99.20

Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells

Rah, S.Y.; Mushtaq, M.; Nam, T.S.; Kim, S.H.; Kim, U.H.; J. Biol. Chem. 285, 21877-21887 (2010)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Mus musculus
5764
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
P56528
-
-
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Mus musculus
5764
-
General Information
General Information
Commentary
Organism
physiological function
calcium signaling messengers nicotinate-adenine dinucleotide phosphate and 2'-phospho-cyclic ADP-ribose are not produced when lymphokine-activated killer cells prepared from CD38 knock-out mice are treated with interleukin IL-8. Application of 2'-phospho-cyclic ADP-ribose to lymphikine-activated killer cells induces nicotinate-adenine dinucleotide phosphate production, whereas nicotinate-adenine dinucleotide phosphate fails to increase intracellular 2'-phospho-cyclic ADP-ribose levels. IL-8-induced nicotinate-adenine dinucleotide phosphate production is mediated by CD38 activation through the actions of cAMP/Epac/protein kinaseA/Rap1 in lymphokine-activated killer cells and nicotinate-adenine dinucleotide phosphate plays a key role in Ca2+ signaling of IL-8-induced lymphokine-activated killer cell migration.
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
calcium signaling messengers nicotinate-adenine dinucleotide phosphate and 2'-phospho-cyclic ADP-ribose are not produced when lymphokine-activated killer cells prepared from CD38 knock-out mice are treated with interleukin IL-8. Application of 2'-phospho-cyclic ADP-ribose to lymphikine-activated killer cells induces nicotinate-adenine dinucleotide phosphate production, whereas nicotinate-adenine dinucleotide phosphate fails to increase intracellular 2'-phospho-cyclic ADP-ribose levels. IL-8-induced nicotinate-adenine dinucleotide phosphate production is mediated by CD38 activation through the actions of cAMP/Epac/protein kinaseA/Rap1 in lymphokine-activated killer cells and nicotinate-adenine dinucleotide phosphate plays a key role in Ca2+ signaling of IL-8-induced lymphokine-activated killer cell migration.
Mus musculus
Other publictions for EC 2.4.99.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727515
Schmid
CD38: a NAADP degrading enzyme ...
Homo sapiens, Mus musculus
FEBS Lett.
585
3544-3548
2011
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2
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2
2
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727868
Rah
Generation of cyclic ADP-ribos ...
Mus musculus
J. Biol. Chem.
285
21877-21887
2010
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1
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1
1
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726853
Moreschi
NAADP+ synthesis from cADPRP a ...
Aplysia californica, Axinella polypoides, Homo sapiens
Biochem. Biophys. Res. Commun.
345
573-580
2006
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727857
Graeff
Acidic residues at the active ...
Homo sapiens
J. Biol. Chem.
281
28951-28957
2006
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1
1
5
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1
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5
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726898
Bacher
Channelling of substrate promi ...
Oryctolagus cuniculus
Biochem. J.
381
147-154
2004
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6
1
2
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1
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4
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4
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724210
Chini
CD38 is the major enzyme respo ...
Mus musculus, Rattus norvegicus
Biochem. J.
362
125-130
2002
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4
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4
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6
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1
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1
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3
3
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726647
Lee
ADP-ribosyl cyclase and CD38. ...
Aplysia californica, Homo sapiens
Adv. Exp. Med. Biol.
419
411-419
1997
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1
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8
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727816
Aarhus
ADP-ribosyl cyclase and CD38 c ...
Aplysia californica, Homo sapiens
J. Biol. Chem.
270
30327-30333
1995
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2
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