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Information on EC 2.3.1.250 - [Wnt protein] O-palmitoleoyl transferase

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IUBMB Comments
The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser209 in human Wnt3a and Ser224 in chicken WNT1 [2,3]. The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo . cf. EC 3.1.1.98, [Wnt protein]-O-palmitoleoyl-L-serine hydrolase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[Wnt]-L-serine
=
+
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
Synonyms
porcn, mom-1, mporc, mporcd, xporc, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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