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Results 1 - 10 of 18 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250C187A site-directed mutagenesis, increase in Wnt signaling activity of about 1.5fold upon expression of PORCNC187A compared to wild-type PORCN 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250C375X site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250C381X site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250C385X site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250H341A site-directed mutagenesis, catalytic active site mutant, Wnt signaling inactive mutant 734194
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250H341A site-directed mutagenesis, catalytically inactive mutant 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250H341A site-directed mutagenesis, the mutation reduces Wnt signaling relative to wild-type PORCN 734745
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250H341D site-directed mutagenesis, catalytically inactive mutant 733699
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250H341Q site-directed mutagenesis, catalytically inactive mutant 733699
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.250more generation of three different deletion mutants of the enzyme lacking residues 1-34, 1-66, or 1-110 (DELTA34, DELTA66, and DELTA110), the mutants show affeced N-glycosylation of Wingless protein, because the mutant enzymes cannot bind to Wingless, overview 733769
Results 1 - 10 of 18 > >>