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Information on EC 2.1.1.299 - protein N-terminal monomethyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.299 protein N-terminal monomethyltransferase
IUBMB Comments
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
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Word Map
  • 2.1.1.299
  • histone
  • methyltransferases
  • monomethylation
  • intellectual
  • disability
  • brachydactyly
  • stature
  • dysmorphisms
  • trimethylation
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
N-terminal-(A,P,S)PK-[protein]
=
+
N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Synonyms
nrmt2, mettl11b, n-terminal monomethylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
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