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Literature summary for 2.1.1.299 extracted from

  • Huang, R.
    Chemical biology of protein N-terminal methyltransferases (2019), ChemBioChem, 20, 976-984 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures with PDB IDs 5UBB and 6DUB Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
Homo sapiens 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine Homo sapiens
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N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VVY1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
additional information NTMT2 is predominantly expressed in heart and skeletal muscle tissues Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the substrate recognition motif is X-P-K/R. Although NTMT2 is proposed to be a monomethylase, it can also fully methylate both GPKRIA and PPKRIA peptides, but to a low level. NTMT2 is able to methylate hexamer peptides Homo sapiens ?
-
-
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
-
Homo sapiens N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
?

Synonyms

Synonyms Comment Organism
METTL11B
-
Homo sapiens
NRMT2
-
Homo sapiens
NTMT2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
malfunction the N209I endometrial and P211S lung cancer mutants decrease the trimethylation level of RCC1, whereas the Q144H lung cancer mutant increases the trimethylation level of RCC1 with minimal levels of mono- and dimethylated RCC1. For NTMT2, the V224L breast cancer mutant shows marginal methylation activity for methylation states. Those data infer that methylation levels may play different roles in different cancers Homo sapiens
metabolism protein alpha-N-terminal methylation is catalyzed by prokaryotic and eukaryotic protein N-terminal methyltransferases. The prevalent occurrence of this methylation in ribosomes, myosin, and histones implies its function in protein-protein interactions. Functions of methylated glycine, alanine, and serine, overview Homo sapiens
additional information substrate recognition and catalytic mechanisms, overview Homo sapiens