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Information on EC 2.1.1.132 - precorrin-6B C5,15-methyltransferase (decarboxylating)

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IUBMB Comments
The enzyme, which participates in the aerobic adenosylcobalamin biosynthesis pathway, has S-adenosyl-L-methionine-dependent methyltransferase and decarboxylase activities. The enzyme is a fusion protein with two active sites; one catalyses the methylation at C15 and the decarboxylation, while the other catalyses the methylation at C5.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes
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Synonyms
CobL, GenBank L12005-derived protein, Genbank L12006-derived protein, GenBank U67594-derived protein GI 1500413, Gene cbiE precorrin 6y methylase, Gene cbiT precorrin methylase, Methyltransferase precorrin 6y (Salmonella typhimurium strain LT2 gene cbiE), methyltransferase, precorrin 6y, Methyltransferase, precorrin 6y (Methanococcus jannaschii), Methyltransferase, precorrin 6y (Salmonella typhimurium strain LT2 gene cbiT), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2
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S-adenosyl-L-methionine + precorrin-6B = S-adenosyl-L-homocysteine + precorrin-7 + CO2
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(1a)
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S-adenosyl-L-methionine + precorrin-7 = S-adenosyl-L-homocysteine + precorrin-8X
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(1b)
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PATHWAY SOURCE
PATHWAYS
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