Information on EC 1.8.98.5 - H2:CoB-CoM heterodisulfide,ferredoxin reductase

for references in articles please use BRENDA:EC1.8.98.5
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The expected taxonomic range for this enzyme is: Methanothermobacter marburgensis

EC NUMBER
COMMENTARY hide
1.8.98.5
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RECOMMENDED NAME
GeneOntology No.
H2:CoB-CoM heterodisulfide,ferredoxin reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Methane metabolism
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Metabolic pathways
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
CoB,CoM,ferredoxin:H2 oxidoreductase
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
coenzyme B-coenzyme M disulfide + ferredoxin + 2 H2
coenzyme B + coenzyme M + reduced ferredoxin2- + 2 H+
show the reaction diagram
coenzyme B-coenzyme M disulfide + metronidazole + 2 H2
coenzyme B + coenzyme M + reduced metronidazole2- + 2 H+
show the reaction diagram
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
potassium phosphate
complex is most active in presence of 1.6 M potassium phosphate; complex is most active in presence of 1.6 M potassium phosphate; complex is most active in presence of 1.6 M potassium phosphate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110
HdrABC complex with 100% H2 in the gas phase, pH 7.6, 60°C; HdrABC complex with 100% H2 in the gas phase, pH 7.6, 60°C; HdrABC complex with 100% H2 in the gas phase, pH 7.6, 60°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE