EC Number   |
Cofactor |
Reference |
|---|
    1.8.98.5 | FAD |
- |
764153, 764753 |
| 1.8.98.5 | FAD |
electron-bifurcating FAD in HdrA |
764200 |
| 1.8.98.5 | FAD |
the bifurcating FAD of HdrA sequentially accepts two electrons from the [2Fe-2S] cluster that contrasts with other characterized FBEB enzymes for which a hydride is donated to FAD |
764753 |
| 1.8.98.5 | FAD |
the enzyme contains approximately 0.9 mol nickel |
744833 |
| 1.8.98.5 | Fe-S center |
two [4Fe-4S] clusters of the inserted ferredoxin (Fd) domain |
764153 |
| 1.8.98.5 | Fe-S center |
[4Fe-4S] clusters. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs |
764200 |
| 1.8.98.5 | Ferredoxin |
- |
764153, 764660, 764753, 764762 |
| 1.8.98.5 | Ferredoxin |
standard HdrC-like components consist of a Fd-like domain |
764200 |
| 1.8.98.5 | Ferredoxin |
standard HdrC-like components consist of a Fd-like domain. The TrxR domain is flanked by attached N- and C-terminal domains and an inserted Fd domain hosting one, two and again two [4Fe-4S] clusters, respectively. The low-potential acceptor Fd was not found in the complex, but electron transfer to it most possibly involves the [4Fe-4S] cluster of the Fd domain in HdrA |
764200 |
| 1.8.98.5 | more |
a methanophenazine-like cofactor functions as an electron carrier between the hydrogenase/formate dehydrogenase and the heterodisulfide reductase, cf. EC 1.8.98.1 |
764660 |
