EC Number |
Subunits |
Reference |
---|
1.8.98.5 | ? |
x * 51000 + x * 41000 + x * 17000, SDS-PAGE |
-, 744179 |
1.8.98.5 | heterododecamer |
(MvhAGD-HdrABC)2 , 1 * 72000, HdrA, + 1 * 33000, HdrB, + 1 * 21000, HdrC, + 1 * 53000, MvhA, + 1 * 34000, MvhG, + 1 * 16000, MvhD, SDS-PAGE |
764200 |
1.8.98.5 | heterohexamer |
2 * 80000 + 2 * 51000 + 2 * 41000 + 2 * 36000 + 2 * 21000 + 2 * 17000, SDS-PAGE |
-, 744833 |
1.8.98.5 | More |
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA (72 kDa), HdrB (33 kDa) and HdrC (21 kDa) and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA (53 kDa), MvhG (34 kDa) and MvhD (16 kDa). Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex |
764200 |
1.8.98.5 | More |
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex |
-, 764200 |
1.8.98.5 | More |
three Hdr complexes employing two Vhu domains [(Vhu)2Hdr complex], two Fdh domains [(Fdh)2Hdr complex], or one Vhu and one Fdh domain forming a heterocomplex (Fdh/Vhu/Hdr complex) |
-, 764153 |