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Information on EC 1.4.1.18 - lysine 6-dehydrogenase
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1.4.1.18 lysine 6-dehydrogenaseIUBMB Comments
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].
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Word Map
- 1.4.1.18
-
deamination
- tumefaciens
-
agrobacterium
- saccharopine
-
5-carboxylate
-
corynebacterium
- pomeroyi
-
non-proteinogenic
-
silicibacter
-
nad-dependent
- glutamicum
-
pyrroline
-
l-pipecolic
- tetramer
- albicans
- analysis
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
l-lysine 6-dehydrogenase, l-lysine epsilon-dehydrogenase, lysine 6-dehydrogenase, lys 6-dh, l-lysine 6-dehydrogenase (deaminating), 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
L-lysine 6-dehydrogenase
L-lysine 6-dehydrogenase (deaminating)
L-lysine epsilon-dehydrogenase
-
-
-
-
LysDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
-
-
-
-
L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
reaction mechanism, overview
L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
reaction mechanism, overview
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
L-lysine:NAD+ 6-oxidoreductase (deaminating)
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].
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CAS REGISTRY NUMBER
COMMENTARY
89400-30-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-phenylbutan-1-one + NADH + H+ + NH3
(1R)-1-phenylbutan-1-amine + NAD+ + H2O
mutant F173A, 10 mM, 87% conversion, product in R-configuration, 99.8% ee
-
-
?
1-phenylethan-1-one + NADH + H+ + NH3
(1R)-1-phenylethan-1-amine + NAD+ + H2O
mutant F173A, 10 mM, 99% conversion, product in R-configuration, 99.9% ee
-
-
?
1-phenylpentan-1-one + NADH + H+ + NH3
1-phenylpentan-1-amine + NAD+ + H2O
mutant F173A, 10 mM, 36% conversion
-
-
?
1-phenylpropan-1-one + NADH + H+ + NH3
(1R)-1-phenylpropan-1-amine + NAD+ + H2O
mutant F173A, 10 mM, 98% conversion, product in R-configuration, 99.9% ee
-
-
?
2,3-dihydro-4H-1-benzopyran-4-one + NADH + H+ + NH3
(4R)-3,4-dihydro-2H-1-benzopyran-4-amine + NAD+ + H2O
mutant F173A, 10 mM, 82% conversion, product in R-configuration, 99.4% ee
-
-
?
3,4-dihydronaphthalen-1(2H)-one + NADH + H+ + NH3
(1R)-1,2,3,4-tetrahydronaphthalen-1-amine + NAD+ + H2O
mutant F173A, 10 mM, 79% conversion, product in R-configuration, 99% ee
-
-
?
4-methylpentan-2-one + NADH + H+ + NH3
(2R)-4-methylpentan-2-amine + NAD+ + H2O
mutant F173A, 10 mM, 76% conversion, product in R-configuration, 97% ee
-
-
?
6-oxoheptanoic acid + NADH + H+ + NH3
(6S)-6-aminoheptanoic acid + NAD+ + H2O
mutant F173A, 10 mM, 99% conversion, product in S-configuration, 99% ee
-
-
?
6-oxohexanoic acid + NADH + H+ + NH3
L-lysine + NAD+ + H2O
mutant F173A, 10 mM, 99% conversion
-
-
?
cyclohexanone + NADH + H+ + NH3
cyclohexanamine + NAD+ + H2O
mutant F173A, 10 mM, 86% conversion
-
-
?
hexan-2-one + NADH + H+ + NH3
(2R)-hexan-2-amine + NAD+ + H2O
mutant F173A, 10 mM, 87% conversion, product in R-configuration, 99% ee
-
-
?
L-lysine + 3-acetylpyridine-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH
L-lysine + NAD+ + H2O
2-aminoadipate-6-semialdehyde + NADH + H+ + NH3
-
cyclizes nonenzymatically to DELTA1-piperidine-6-carboxylate
-
?
L-lysine + NADP+
2-aminoadipate-6-semialdehyde + NADPH
22% of activity with NAD+
cyclizes nonenzymatically to DELTA1-piperidine-6-carboxylate
-
?
L-lysine + nicotinamide guanine dinucleotide + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + nicotinamide guanine dinucleotide
-
-
-
?
pentan-2-one + NADH + H+ + NH3
(2R)-pentan-2-amine + NAD+ + H2O
mutant F173A, 10 mM, 86% conversion, product in R-configuration, 89% ee
-
-
?
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
-
i.e. DELTA1-piperidein-6-carboxylate, spontaneous nonenzymatical reaction, spontaneous reaction
-
?
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
-
-
spontaneous reaction
-
?
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
-
i.e. DELTA1-piperidein-6-carboxylate, spontaneous nonenzymatical reaction, spontaneous reaction
-
?
L-lysine + 3-acetylpyridine-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH
-
-
-
?
L-lysine + 3-acetylpyridine-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH
-
-
-
-
?
L-lysine + deamino-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + deamino-NADH
-
-
-
?
L-lysine + deamino-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + deamino-NADH
-
-
-
-
?
L-lysine + NAD(P)+ + H2O
(S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
-
-
-
?
L-lysine + NAD(P)+ + H2O
(S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
-
-
-
?
L-lysine + NAD+ + H2O
(S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
-
-
-
-
?
L-lysine + NAD+ + H2O
(S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
-
-
-
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
reaction A-stereospecific
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
reaction A-stereospecific
product is spontaneosly converted into delta1-piperideine-6-carboxylate
ir
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
no activity with D-lysine
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
function in lysine catabolism
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
function in lysine catabolism
product is spontaneosly converted into delta1-piperideine-6-carboxylate
ir
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
involved in biosynthesis of piperidine nucleus of alkaloids
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
S-(beta-aminoethyl)-L-cysteine + NAD+
?
-
3% of the activity with L-lysine
-
-
?
S-(beta-aminoethyl)-L-cysteine + NAD+
?
11% of activity with L-lysine
-
-
?
additional information
?
-
the alpha-carboxyl group is crucial for productive substrate binding and amination. No substrates: hexanal, heptanal, 2-heptanone, 2-octanone, acetophenone and alpha-chromanone
-
-
-
additional information
?
-
active site structure, overview
-
-
?
additional information
?
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
additional information
?
-
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
additional information
?
-
active site structure, overview
-
-
?
additional information
?
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-lysine + NAD+ + H2O
2-aminoadipate-6-semialdehyde + NADH + H+ + NH3
-
cyclizes nonenzymatically to DELTA1-piperidine-6-carboxylate
-
?
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
-
i.e. DELTA1-piperidein-6-carboxylate, spontaneous nonenzymatical reaction
-
?
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
-
i.e. DELTA1-piperidein-6-carboxylate, spontaneous nonenzymatical reaction
-
?
L-lysine + NAD(P)+ + H2O
(S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
-
-
-
?
L-lysine + NAD(P)+ + H2O
(S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
-
-
-
?
L-lysine + NAD+ + H2O
(S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
-
-
-
-
?
L-lysine + NAD+ + H2O
(S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
-
-
-
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
function in lysine catabolism
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
function in lysine catabolism
product is spontaneosly converted into delta1-piperideine-6-carboxylate
ir
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
involved in biosynthesis of piperidine nucleus of alkaloids
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
-
-
product is spontaneosly converted into delta1-piperideine-6-carboxylate
?
additional information
?
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
additional information
?
-
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
additional information
?
-
the enzyme catalyzes the reductive deamination of the epsilon-amino group and acts as a type of NAD+-dependent amine dehydrogenase producing DELTA1-piperideine-6-carboxylate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
preferred cofactor, binding structure, overview. The enzyme makes use of pro-R-specific hydride transfer between the two hydrides at C-4 of NADH with type A specificity
additional information
both NAD+ and NADP+ are able to serve as the coenzyme for Pyrococcus horikoshii LysDH, although the reaction rate with NADP+ is only 7.8% of that with NAD+, when L-lysine is the substrate
-
additional information
-
both NAD+ and NADP+ are able to serve as the coenzyme for Pyrococcus horikoshii LysDH, although the reaction rate with NADP+ is only 7.8% of that with NAD+, when L-lysine is the substrate
-
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6-amino-n-caproate
inhibition 20% by 10 mM 6-amino-n-caproate
DTNB
-
almost complete inhibition in presence of NAD+, 40% inhibition in presence of L-lysine
N-ethylmaleimide
-
complete inhibition at 1 mM after 10 min incubation
p-chloromercuribenzoate
-
complete inhibition at 0.01 mM after 10 min incubation, reversible with 2-mercaptoethanol or dithiothreitol
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Dehydration
Fermentative production of L-pipecolic acid from glucose and alternative carbon sources.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10
9.7
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7 - 10.8
approx. 35% of maximal activity at pH 7.0, approx. 50% of maximal activity at pH 10.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50 - 95
maximum activity at about 95°C and an extraordinary drop off in activity with reduction in temperature, the activity at 50°C is only about 1/170th of that at 95°C
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