Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-lysine | increased activity after 10 min preincubation | Agrobacterium tumefaciens |
General Stability | Organism |
---|---|
L-lysine stabilizes | Agrobacterium tumefaciens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DTNB | almost complete inhibition in presence of NAD+, 40% inhibition in presence of L-lysine | Agrobacterium tumefaciens | |
HgCl2 | complete inhibition at 0.001 mM after 10 min incubation | Agrobacterium tumefaciens | |
N-ethylmaleimide | complete inhibition at 1 mM after 10 min incubation | Agrobacterium tumefaciens | |
p-chloromercuribenzoate | complete inhibition at 0.01 mM after 10 min incubation, reversible with 2-mercaptoethanol or dithiothreitol | Agrobacterium tumefaciens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.059 | - |
NAD+ | - |
Agrobacterium tumefaciens | |
1.85 | - |
deamino-NAD+ | - |
Agrobacterium tumefaciens | |
3.13 | - |
3-acetylpyridine-NAD+ | - |
Agrobacterium tumefaciens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
ultracentrifugation in presence of L-lysine | Agrobacterium tumefaciens |
165000 | - |
gel filtration in presence of L-lysine | Agrobacterium tumefaciens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine + NAD+ + H2O | Agrobacterium tumefaciens | - |
alpha-aminoadipate delta-semialdehyde + NH3 + NADH | product is spontaneosly converted into delta1-piperideine-6-carboxylate | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Agrobacterium tumefaciens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7.5 | - |
preincubation in absence of L-lysine | Agrobacterium tumefaciens |
15.7 | - |
preincubation in presence of L-lysine | Agrobacterium tumefaciens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine + 3-acetylpyridine-NAD+ + H2O | - |
Agrobacterium tumefaciens | alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH | - |
? | |
L-lysine + deamino-NAD+ + H2O | - |
Agrobacterium tumefaciens | alpha-aminoadipate delta-semialdehyde + NH3 + deamino-NADH | - |
? | |
L-lysine + NAD+ + H2O | - |
Agrobacterium tumefaciens | alpha-aminoadipate delta-semialdehyde + NH3 + NADH | product is spontaneosly converted into delta1-piperideine-6-carboxylate | ? | |
S-(beta-aminoethyl)-L-cysteine + NAD+ | 3% of the activity with L-lysine | Agrobacterium tumefaciens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | after preincubation with NAD+ without L-lysine | Agrobacterium tumefaciens |
tetramer | gel filtration and centrifugation in presence of L-lysine | Agrobacterium tumefaciens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
stable for 10 min in absence of L-lysine, unstable above 40°C | Agrobacterium tumefaciens |
50 | - |
stable for 10 min in presence of L-lysine, unstable above 50°C | Agrobacterium tumefaciens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.7 | - |
- |
Agrobacterium tumefaciens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine-NAD+ | 16% of activity compared with NAD+ | Agrobacterium tumefaciens | |
deamino-NAD+ | 42% of activity compared with NAD+ | Agrobacterium tumefaciens | |
NAD+ | - |
Agrobacterium tumefaciens |