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Information on EC 1.14.19.68 - (S)-canadine synthase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme catalyses an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
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The enzyme appears in viruses and cellular organisms
Synonyms
(S)-tetrahydroberberine synthase, (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming), canadine synthase, CAS-1, CYP719A13, CYP719A21, EC 1.1.3.36, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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