Ligand (S)-tetrahydrocolumbamine

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Basic Ligand Information

Molecular Structure
Picture of (S)-tetrahydrocolumbamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H23NO4
(S)-tetrahydrocolumbamine
KDFKJOFJHSVROC-INIZCTEOSA-N
Synonyms:
5,8,13,13a-tetrahydrocolumbamine, isocorypalmine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-tetrahydroberberine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-tetrahydroberberine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-Adenosyl-L-methionine + (S)-scoulerine = S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-tetrahydroberberine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-Adenosyl-L-methionine + (S)-scoulerine = S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine
show the reaction diagram
S-adenosyl-L-methionine + columbamine + NADPH + H+ = S-adenosyl-L-homocysteine + isocorypalmine + NADP+
show the reaction diagram
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for (S)-tetrahydrocolumbamine

ChEBI
PubChem
ChEBI
PubChem