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Information on EC 1.14.14.8 - anthranilate 3-monooxygenase (FAD) for references in articles please use BRENDA:EC1.14.14.8Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Geobacillus thermodenitrificans
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anthranilate 3-monooxygenase (FAD)
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anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O
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anthranilate degradation IV (aerobic)
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tryptophan metabolism
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Tryptophan metabolism
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anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.
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FADH2-utilizing monooxygenase
FADH2-utilizing monooxygenase
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FADH2-utilizing monooxygenase
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GTNG_3160
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brenda
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brenda
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2-hydroxyphenylacetate + FADH2 + O2
?
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62.79% relative activity
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?
2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2
?
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42.7% relative activity
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD
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highest activity
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
salicylate + FADH2 + O2
?
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49% relative activity
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?
salicylate + FADH2 + O2
? + FAD + H2O
additional information
?
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2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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67.8% of the activity with anthranilate
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?
2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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67.8% of the activity with anthranilate
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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42.7% of the activity with anthranilate
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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42.7% of the activity with anthranilate
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
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?
salicylate + FADH2 + O2
? + FAD + H2O
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49.6% of the activity with anthranilate
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?
salicylate + FADH2 + O2
? + FAD + H2O
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49.6% of the activity with anthranilate
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?
additional information
?
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no substrate: kynurenine, phenol, 2-nitrobenzylic acid, chlorobenzene, naphthalene, naphthol, toluene or ethylbenzene
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additional information
?
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no substrate: kynurenine, phenol, 2-nitrobenzylic acid, chlorobenzene, naphthalene, naphthol, toluene or ethylbenzene
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FADH2
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; FADH2-utilizing monooxygenase, no reaction with FMNH2
additional information
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no cofactor: FMNH2
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151.3
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substrate anthranilate, pH 9.0, 60°C
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9
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; assay at, highest activity
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60
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; assay at, highest activity
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using Ni-NTA chromatography
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expressed in Escherichia coli; expression in Escherichia coli
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transcription level increases highly when anthranilate is used as the sole carbon source
transcription level increases highly when anthranilate is used as the sole carbon source
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transcription level increases highly when anthranilate is used as the sole carbon source
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HPAH_GEOTN
Geobacillus thermodenitrificans (strain NG80-2)
494
56164
Swiss-Prot
A0A2S6ULV6_9PROT
508
57310
TrEMBL
A0A2P5VL78_9PROT
488
54968
TrEMBL
A0A2H5YZ54_9BACT
414
47328
TrEMBL
A0A1Y5YQS7_BACCE
480
54278
TrEMBL
A0A2S6R4A3_9PROT
496
55825
TrEMBL
A0A0K6J6J0_BACCE
490
55743
TrEMBL
A0A1Y2MHI6_PSEAH
488
54198
TrEMBL
A0A2S6STT7_9PROT
483
54360
TrEMBL
A0A2S6TZS8_9PROT
497
56298
TrEMBL
A0A1Y0ND52_9BURK
522
58626
TrEMBL
A0A1Y5TI39_9PROT
485
54682
TrEMBL
A0A2S6QDC8_9PROT
496
55481
TrEMBL
A0A2S6S4Q3_9PROT
483
54537
TrEMBL
A0A2M9MUU2_9BACL
481
54497
TrEMBL
A0A1T2ST61_BACCE
477
54371
TrEMBL
A0A2P8B2A7_9ACTN
491
54666
TrEMBL
A0A1C0TYW9_9GAMM
481
54852
TrEMBL
A0A0K6MWQ3_BACIU
346
38743
TrEMBL
A0A1Y5S1S2_9RHOB
502
56439
TrEMBL
A0A1Y6ANM9_BACCE
476
54173
TrEMBL
A0A178X727_9PSEU
486
53126
TrEMBL
A0A2S6Q7L0_9PROT
496
56280
TrEMBL
A0A2S6U561_9PROT
435
48300
TrEMBL
A0A2S6R535_9PROT
317
35304
TrEMBL
A0A0U4NGG8_9BACL
488
55017
TrEMBL
A0A1E8AY95_BACMY
490
55649
TrEMBL
A0A1Y6ACK6_BACCE
490
55700
TrEMBL
A0A0G4JMP8_9BURK
493
55456
TrEMBL
A0A1E8AYH0_BACMY
490
55639
TrEMBL
A0A2S6TDN4_9PROT
502
56492
TrEMBL
A0A178X6F6_9PSEU
484
53256
TrEMBL
A0A1H8THV0_9RHIZ
495
55149
TrEMBL
A0A165U0L1_9RHOB
506
56896
TrEMBL
A0A238LCX8_9RHOB
506
56489
TrEMBL
A0A0M0EHE0_KOMEU
489
55363
TrEMBL
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Liu, X.; Dong, Y.; Li, X.; Ren, Y.; Li, Y.; Wang, W.; Wang, L.; Feng, L.
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2
Microbiology
156
589-595
2010
Geobacillus thermodenitrificans, Geobacillus thermodenitrificans NG80-2
brenda
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